For research purposes only
IGF-1LR3
IGF-1LR3 (Long Arg3 IGF-1) is a recombinant 83-amino acid IGF-1 analog carrying an N-terminal 13-residue extension and an Arg3 substitution that disrupts high-affinity binding to IGF-binding proteins. Eliminating IGFBP sequestration results in 2-3x greater potency at the IGF-1 receptor in cell culture relative to the native protein, while downstream PI3K/AKT and MAPK/ERK cascade activation follows the same IGF-1R-mediated signaling architecture. It is the preferred tool for studies requiring full IGF-1R pathway engagement without the confounding variable of endogenous IGFBP competition. Supplied lyophilized for in vitro research use only.
Select size
$90.00
Specifications
- CAS
- 946870-92-4
- MW
- 9117.5 g/mol
- Formula
- C400H625N111O115S9
- Purity
- >=99.1 HPLC
- Storage
- -20 °C, lyophilized
Research Notes
What is IGF-1LR3?
IGF-1LR3 is a synthetic research compound studied in laboratory settings. It has molecular formula C400H625N111O115S9, a molecular weight of 9117.5 g/mol, CAS 946870-92-4. It is intended for in vitro research use only and is not for human or animal use.
What purity is METATIDE's IGF-1LR3?
METATIDE supplies IGF-1LR3 at >=99.1% purity, verified by third-party HPLC analysis. A certificate of analysis is available on request.
How is IGF-1LR3 supplied?
IGF-1LR3 is supplied as a lyophilized powder in sealed research-grade vials, stored -20 °C, lyophilized, intended for in vitro and laboratory research use only.